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In addition, PDGFR/ amplification, overexpression, and constitutive activation contribute to anti-IGF-IR mAb resistance [179, 180]

Chronic pain, fatigue, medication side effects, and disease-related stress contribute to the increased risk of mental health disorders in this population

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By the time the Wegovy trials were conducted, however, the investigators were well aware of this possible side effect

A separate 2024 study published in Menopause: The Journal of the North American Menopause Society looked at approximately 100 postmenopausal women on semaglutide and found meaningful weight loss alongside improvements in cardiovascular risk markers