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Some people develop a tolerance after months or years on the drug, but others develop a tolerance much sooner

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In these patients, especially those with heart or kidney disease, the drugs improved blood sugar control, reduced the risk of heart and kidney complications, supported weight loss, and lowered the risk of early death

Evaluation of phosphorus and non-phosphorus neutral oligonucleotide backbones for enhancing therapeutic index of gapmer antisense oligonucleotides