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J Biol Chem 265:80018008 Nauck MA, Bartels E, Orskov C, Ebert R, Creutzfeldt W (1993a) Additive insulinotropic effects of exogenous synthetic human gastric inhibitory polypeptide and glucagon-like peptide-1-(7-36) amide infused at near-physiological insulinotropic hormone and glucose concentrations

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Not direct cardiac toxicity

They found that the predominant impact of SGLT-2 inhibitors is on cardiovascular outcome was driven predominantly by reduction in MACE, total death, HHF, MI, stroke, and CV death

Key points Human IGF-1 and LR3 IGF-1 are produced in the P

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