Targeting the epigenome with dietary agents
For collagen fibers to achieve their legendary tensile strength and elasticity, they must undergo a complex biochemical maturation process known as covalent cross-linking, a process entirely dependent on the presence of L-Lysine
Lpez F, Al Ghuzlan A, Zafereo ME , Vander Poorten V, Robbins KT, Hamoir M, Nixon IJ, Tufano RP, Randolph G, Pace-Asciak P, Angelos P, Coca-Pelaz A, Khafif A, Ronen O, Rodrigo JP, S, Palme CE, Mkitie AA, Kowalski LP, Rinaldo A, Ferlito A
While naturally occurring IGF-1 plays a critical role in growth and development, the LR3 modification extends its half-life and dramatically enhances its biological availability making it a favorite for research into athletic performance, muscle rehabilitation, and age-related decline
Neri S, Calvagno S, Mauceri B, Misseri M, Tsami A, Vecchio C, et al
This includes oxygenation, GSH depletion, and localized release of adjuvants or cytokines, thereby removing barriers to dendritic cell activation and facilitating T-cell priming, infiltration, and effector function-essentially fueling the immune response (155, 166, 167)