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That long half-life is also why titration steps are held for about four weeks rather than a few days: it takes several weekly doses for blood levels to plateau at each new rung of the ladder before the next increase makes sense

doi: 10.1056/NEJMoa1600869 [DOI] [PMC free article] [PubMed] [Google Scholar] 14.Wiggins T, Antonowicz SS, Markar SR