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Unfortunately, reperfusion can cause massive oxidative stress on your cardiovascular system, as the oxygen interacts with metabolites produced by the oxygen-deprived tissues

In the innate immune response, H 2 O 2 /O can regulate the expression of the transcription factors involved in redox reactions, such as NF-B, NRF2, and HIF-1, thereby mediating redox-based epigenetic modifications [204]

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Leonurine ameliorates LPS-induced acute kidney injury via suppressing ROS-mediated NF-B signaling pathway

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Women with OAB may have a proliferative inflammatory response due to a shift in the balance of these cytokines towards a more proinflammatory state and the absence of anti-inflammatory cytokines, which could contribute to the pathophysiology of this disease