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The enrolment of 37 participants in each treatment group was calculated to provide a combined power of 80.6% to detect a treatment difference corresponding to 20 nmol l 1 h 1 and 650 nmol l 1 h 1 for the first and second insulin secretion phases, respectively, assuming a corresponding SD of 23 nmol l 1 h 1 and 830 nmol l 1 h 1