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Since cuprizone regimen was several times higher than those regularly used in cuprizone studies (62) we used simple tests ( Tables 1-3 ) to determine animal responsiveness and impairment

It comes from natto, a Japanese dish made from soybeans fermented with a bacterium ( Bacillus subtilis )

The gut microbiota, which accommodate approximately 10 13 10 14 cells belonging to a diverse group of microorganisms [112] (equivalent to over 3 million genes), play a key role in human health by determining the development of conditions linked with the nervous system, autoimmunity, metabolism, and inheritance [113,114]

The goal is to maximize its regenerative and reparative benefits while minimizing any temporary adverse observations

In conclusion, the current evidence suggests that ALC seems effective and safe in the treatment of PNP, especially of diabetic PNP