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doi: 10.1007/s00125-013-3145-0 54 HoganAETobinAMAhernTCorriganMAGaoatsweGJacksonRet al

Mechanism of Action in Research Models GIP receptor activation is studied in the context of incretin signaling, glucose-responsive pathways, and insulin physiology areas relevant to type 2 diabetes research models

Post hoc evaluations of the SUSTAIN 6 trial revealed that semaglutide markedly increased the incidence of diabetic retinopathy complications in individuals with a history of retinopathy, especially among insulin users, presumably due to the swift deterioration of pre-existing retinopathy following rapid glycemic control [91]

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