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Shin Y-K, Martin B, Golden E, Dotson CD, Maudsley S, Kim W, et al

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Firstly, the full-length GLP-1 (137) was found to be catalysed by endopeptidase to the biologically active GLP-1 (737)

Its concurrent engagement of GLP-1R, GIPR, and GCGR distinguishes it structurally and pharmacologically from both selective GLP-1R agonists such as semaglutide and dual GLP-1R/GIPR agonists such as tirzepatide

[DOI] [PMC free article] [PubMed] [Google Scholar] 79