So, as it relates just to our environment, (more on the massive role genetics and our brain play in obesity here ), a gross oversimplification at the highest level is: Life used to be exercise, it no longer is Weve created hyper palatable, calorie dense, crave-worthy food Weve made food cheap (relatively speaking) and remarkably easy to acquire What happens if we remove the craving part
For example, a recent analysis of the FDAs reporting system (FAERS) highlighted that taste disturbances (dysgeusia) are noted more frequently by patients using GLP-1RAs in everyday practice than in clinical trial reports (161)
Spencer, a psychiatrist specializing in metabolic psychiatry, puts it plainly: These systems are inseparable
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If you are considering semaglutide or similar medications and have concerns about how they might interact with your orthopedic care or recovery plan, we encourage you to schedule a consultation
The findings deliver early evidence that semaglutide may offer a dual benefit, targeting obesity and key reproductive challenges associated with the condition, including irregular menstruation and impaired fertility. Clare Thompson, MBBS, BSc, nMRCGP Separately, a review of five randomized controlled trials presented at ENDO 2026 found that GLP-1 drugs, such as semaglutide and liraglutide, do not appear to harm male fertility and may even improve testosterone levels and sperm quality in some men with obesity
