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PMC 1135589

Apmis 119 , 93102 (2011)

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Glutathione S-transferases (GSTs) catalyze the conjugation of GSH to a broad range of electrophilic compounds, including endogenous signaling molecules, reactive aldehydes such as 4-hydroxynonenal (4-HNE), and heavy metals 13,14

There are several categories of enzymes involved in the metabolism of lipophilic xenobiotics and their conversions into less toxic compounds exhibiting increased hydrophilicity (Figure 2)

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