dpp-4 inhibitor with glp-1 receptor agonist combination not recommended ada The Role of Inhibitors in the Treatment Algorithm of Type 2 Diabetes Mellitus: When to Select, What to Expect GLP-1 receptor agonists vs. DPP-4

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Preclinical studies document stimulation of collagen and glycosaminoglycan synthesis, upregulation of antioxidant enzymes including superoxide dismutase, and activation of matrix metalloproteinase pathways involved in tissue remodeling and scar resolution

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These findings were corroborated by Wagner et al., who identified LPS-specific impairment of diastolic Ca 2+ clearance mechanisms

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