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While the greater amount of cellular reduced GSH is found in the cytosol and mitochondria, the endoplasmic reticulum becomes a reservoir of small concentrations of the oxidized form of GSH (GSSG)

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NAC (N-acetylcysteine) as precursor: Rather than supplementing glutathione directly, NAC provides the rate-limiting amino acid (cysteine) for endogenous glutathione synthesis

Glutathione is known as the master antioxidant because it not only fights the bad guys but also supports other antioxidants in the body