Relevant preclinical studies have demonstrated that Ex-4, by acting on GLP-1R, inhibits the PI3K/Akt signaling pathway and increases the expression of Caspase-3 and E-cadherin, thereby promoting apoptosis in human ovarian cancer cells and reducing their metastasis [72]
Edited by: Rucker RB, Sultie JW, McCormick, DB, Machlin LJ
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(2023) 52:e12734