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As a small molecule synthesized through conventional organic chemistry, orforglipron can be produced at a fraction of the cost of peptide-based GLP-1 agonists, which require complex solid-phase peptide synthesis, extensive purification, and cold-chain distribution

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What is documented about the two peptides comes overwhelmingly from animal studies, in which they have generally been well tolerated at the doses tested

Milazzo C, Mientjes EJ, Wallaard I, Rasmussen SV, Erichsen KD, Kakunuri T, et al

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Authorship All named authors meet the International Committee of Medical Journal Editors (ICMJE) criteria for authorship for this article, take responsibility for the integrity of the work as a whole and have given their approval for this version to be published