To test if the ferritinophagy-associated effect is an off-target mechanism of Auranofin or a consequence of general TrxR inhibition, we treated LU-NB-1 organoids with other TrxR inhibitors with different chemical structures
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Others notice the effect weakening by week four or five
Subsequently, five size-matching islets were selected per technical replica and transferred to 17 mM glucose (high glucose) or 17 mM glucose + 100 nM Exendin-4 (high glucose + Ex4) KRBH to measure insulin secretion
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