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Concurrently, GLP-1 also reduces fat build-up in the liver by activating AMPK, which then inhibits fatty acid synthesis while promoting the breakdown of fatty acids (beta-oxidation), leading to less lipid droplet accumulation in hepatocytes

It helps turn the fat from our food into energy

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Discussion To our knowledge, this study represents the largest population-based analyses investigating whether GLP1-RA medication is associated with reduced risks of depression or anxiety in DM patients

Funding Open Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature

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