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Data supporting musculoskeletal benefits are limited to rat and in vitro studies, and caution is recommended when extrapolating available rodent research to the clinical setting

These findings, together with comparative structure analysis, time-lapse microscopy, and phosphoproteomics, reveal unique signaling signatures for GLP-1R agonists at the level of receptor conformation, functional selectivity, and location bias, thus associating signaling neighborhoods with functionally distinct cellular outcomes and clinical consequences

The gradual onset allows the body to adapt to the medication whilst minimising adverse effects, particularly gastrointestinal symptoms that can occur with rapid dose escalation

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Eur J Anaesthesiol

doi: 10.1016/j.tcb.2022.02.009 50 ZhuJBerisaMSchworerSQinWCrossJRThompsonCB