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Side effects are usually mild, like redness or tenderness at the injection site, and they disappear quickly

For example, antibodies may enable viral entry into FcR-bearing cells, bypassing specific receptor-mediated entry

However, investigation of these factors in preclinical studies is limited due to the time and expense of generating transgenic mice and the variability of the currently available rodent models 20

In glioma cells IGFBP-2 is well known to act as an oncogene and its increased expression is associated with poor prognosis of GBM [41]

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