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Bannasch 2003

Some evidence suggests that in AD, dysregulation of tight junction proteins, increased matrix metalloproteinase signaling, and degeneration and loss of pericytes may all contribute to BBB leakage, leading to the accumulation of numerous blood-derived neurotoxic proteins in the brain, causing neuroinflammation and oxidative stress

Responsible play hinges on awareness

Animal models contribute systemic context enabling evaluation of cognitive outcomes, neuroimmune responses, and long-term progression which are beyond the scope of cell-based systems

Manufactured under controlled conditions, it is intended strictly for analytical and laboratory research applications

Wells says