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Evidence suggests that bile acids could have therapeutic potential in immune-mediated skin diseases: in an IL23 minicircle-induced psoriasiform dermatitis model, oral or intravenous administration of LCA, DCA, and 3-oxoLCA significantly decreased ear erythema and skin thickening, suppressed IL17 A production, and blocked CCL20CCR6-mediated T cell migration [153]
Netea MG, Joosten LA, Latz E, et al
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Thyroid autoantibodies display both original antigenic sin and epitope spreading
