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In one embodiment of the present invention, the peptide Ac-Nle-cyc/o(-Asp-His-D-Phe- Arg-Trp-Lys)-OH is employed for manufacture of a medicament for treatment by nasal administration, the PDE-5 inhibitor is employed for manufacture of a medicament for treatment by oral administration, and the desired pharmacological response is the ability to attain or sustain an erection of sufficient rigidity for sexual intercourse
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