It also reduced a secondary kidney composite outcome (sustained 50% eGFR decline, ESKD, or renal death) by 44%
Effects of once-weekly semaglutide on appetite, energy intake, control of eating, food preference, and body weight in subjects with obesity
Most people deep in the GLP-1 research rabbit hole know about semaglutide injections such as Ozempic for type 2 diabetes and Wegovy for weight loss
It can include grooming, skin care and exercise, but it is also associated with more intensive interventions such as plastic surgery, orthodontics and hair transplants
That number is not just large in absolute terms, it is the largest weight-loss signal ever reported in a randomized Phase 3 trial of a GLP-1-class compound, and it arrived with additional secondary findings that reframe what "GLP-1 therapy" could eventually mean: a 75.8% reduction in osteoarthritis pain, a roughly 20% drop in LDL cholesterol, and a 72% reversal rate of prediabetes to normoglycemia in the affected subpopulation
Not as potent as medication While certain foods and dietary strategies can increase GLP-1 naturally, the magnitude is far less than what is achievable with medications