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Introduction Non-alcoholic fatty liver disease (NAFLD) is an emerging metabolic disorder around the world, which is featured by excessive hepatic lipid deposition without preexisting liver diseases caused by alcohol abuse ( Recently, natural products play a pivotal role in drug discovery, which also provide new clues to molecular mechanisms of diseases ( in vitro and in vivo ( Dimocarpus longana , Phyllanthus emblica , Phyllanthus reticulatus , and Geranium wilfordii ( in vivo and in vitro by inhibiting Notch signal pathway ( The pathogenesis of NAFLD is complex, and multiple mechanisms may contribute to hepatic lipid deposition ( Materials and methods Animals and treatments Male C57BL/6 mice (four-week-old) were purchased from Beijing SPF experimental animal Technology Co., Ltd