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That doesnt preclude them from being used in the context of CKD, just that they require extra caution and in some patients are likely contraindicated

Any changes people notice may be due to placebo effects, increased awareness around eating, or temporary water weight changes rather than true fat loss

SUGGESTED USAGE: For best results, use as directed

Br J Anaesth 113:1222 Wang J, Yu X, Wang Y, Xu J, Wang Z, Zhang Y (2024) Ultrasonic assessment of gastric solid contents in patients undergoing upper endoscope with sedation

Flexibility: Can be taken at any time of day, with or without food

This is why weekly dosing works: the old dose is still partially active when you inject the new one, creating a steady therapeutic window