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They are not FDA-approved for this indication, but the evidence is accumulating

Esther Bodde , Cosmetic & Medical Physician (MD) Last updated: March 2026 References: Trachy et al

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This particular form represents the most reduced and chemically reactive state of cobalamin, rendering it highly receptive to binding a methyl group from a form of vitamin B9 called 5-methyltetrahydrofolate, the product of methylenetetrahydrofolate reductase (MTHFR), to generate methylcobalamin (MeCbl)

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