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Oxidative Stress and Antioxidant Defense

We (41), and others (42), have shown that the GLP-1R plays an important role in the control of beta cell mitochondrial function, a key process for optimal insulin secretion (43), with our recent interactome results unveiling direct interactions between GLP-1R and cholesterol biosynthesis and metabolism factors located at ER-mitochondria membrane contact sites (41)

Genetic Predispositions and Metabolic Readiness for GLP-1 Therapy Individual response to GLP-1 therapy varies significantly based on genetic variants in appetite regulation and glucose metabolism pathways

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Cell 181 , 271280.e8 (2020)