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A team led by Chia-Yen Jane Shu, a researcher at 23andMe, identified the genetic variants that cause these different drug responses by analyzing the genomes of 27,885 people who had taken GLP-1 medications

Without sufficient methionine, dietary fats accumulate in liver tissue rather than entering circulation for oxidation, creating the metabolic state called hepatic steatosis

However, further large-scale studies are warranted to validate these results

doi: 10.1016/j.exger.2005.05.007

Gene expression profiling of the PPAR-alpha agonist ciprofibrate in the cynomolgus monkey liver

The result was an epidemic of vitamin B12 deficiency, especially in the northern climates of Europe, Russia, and North America