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Ascorbate is oxidized to dehydroascorbate in plasma, which is recycled back to ascorbate by GSH as well as by several enzyme systems in erythrocytes, neutrophils, endothelial cells and hepatocytes

The central hypothesis is that EECs contribute to the pathogenesis of inflammatory bowel diseases (IBD) due to their role in endocrine-immune crosstalk, particularly via GLP-1's influence on intraepithelial lymphocytes and metabolic-inflammatory responses

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major medical organizations (ACOG, AAP) continue to recommend acetaminophen as first-line treatment for fever and pain in pregnancy What the observational literature shows: Associations between prenatal acetaminophen use and neurodevelopmental outcomes in some studies