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Given this situation it is particularly concerning that MDA campaigns show that PZQ cure rates are often less than 50% and modeling studies demonstrating that these campaigns with PZQ alone are unlikely to interrupt transmission, and once MDA is suspended, the prevalence of infection is likely to rebound to pre-MDA levels 9,10,11

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Gillis, Kliewer, et al., 2020) and failure to replicate the original findings from arrestin2 knockout mice that supported this concept (Kliewer et al., 2020)

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