Interestingly, 7 days of relatively low Mn exposure reduced TH-expressing cells in neuron-glial cultures, not in neuron cultures alone, indicating glial cells may exacerbate Mn toxicity in neurons (Zhang et al., 2010)
Solid documentation COA was easy to find, reordering now
Mortensen PB, Hansen HE, Pedersen B, Hartmann-Andersen F, Husted SE: Acute valproate intoxication: biochemical investigations and hemodialysis treatment
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This research was funded by VtR Inc-CGU (SCRPD1L0221), DOXABIO-CGU (SCRPD1K0131), and a CGU grant (UZRPD1L0011, UZRPD1M0081)
Rhythm also announced that it has initiated a Part D arm in the Phase I trial of MC4R agonist RM-718 that will enroll up to 20 patients with PWS