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N Engl J Med 2019;380:347-57.ArticlePubMed 39

Phase 3 (Confirmation): Confirms effectiveness, compares the drug to existing treatments or placebo, and monitors safety in 1,0003,000 patients

This is higher than other GLP-1s, which had discontinuation rates of 6.1% (tirzepatide), 8.0% (semaglutide) and 10.3% (orforglipron)

Prescriptions are now arriving from a broader range of sources, including traditional clinics, telehealth platforms, and specialized weight management services

While these are natural effects of fat reduction, they can impact how we feel about our appearance

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