Based on preclinical (animal and cellular) data only, inhibition of NNMT by 5-Amino-1MQ is theorised to: Raise intracellular NAD+ levels Activate SIRT1 and other sirtuins (proteins linked to metabolic regulation) Reduce fat cell (adipocyte) size and proliferation Improve insulin sensitivity These effects have been demonstrated in mouse models (Neelakantan et al., 2019), but robust human clinical trial data are currently absent
Methionine helps form SAM (S-adenosyl methionine), which is the activated form of methionine
Over weeks two through four, your bone marrow produces new, healthy, normal-sized cells, which can improve endurance, restore a healthier skin tone, and reduce symptoms like heart palpitations tied to anemia
The example subQ doses fit a 0.5 mL barrel
PMID: 29155147 View source Kraus D, et al
Pharmacokinetic modeling and clinical experience support this approach, though no head-to-head randomized trial has compared 1.5 mg twice weekly versus 2.5 mg once weekly
