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Ribonucleotide reductase regulatory subunit M2 (RRM2, a structural unit essential for DNA replication and repair) maintains intracellular GSH by protecting GLC from degradation to exert an anti-ferroptosis effect (Yang Y

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At the same time, the elevated HO-1 expression helps to scavenge free radicals such as peroxynitrite, which is achieved through the overexpression of BV, thus ultimately inhibiting the process of lipid peroxidation [83]

Yet, this perceived safety often ignores medical reality

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