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Dosing matters because GHK-CU works through cellular signaling rather than direct mechanical action

At higher concentrations, MMP2 and MMP9 decrease, preventing excessive collagen degradation

Coodley et al., 1979

Collectively, these studies demonstrate that selenoprotein supplementation can modulate macrophage polarization from a classically activated, pro-inflammatory state toward an alternatively activated, pro-resolving phenotype

Macip, A second generation of senotherapies: the development of targeted senolytics, senoblockers and senoreversers for healthy ageing