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Its rare, but serious enough that regulators in multiple countries are now watching more closely

Some competitors also offer HRT in forms not available through Winona (e.g., Evernow's vaginal estradiol tablets and Alloy's estradiol spray, estradiol gel, and low-dose birth control)

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The FDA retained the boxed warning for endometrial cancer on systemic estrogen-alone products in women with a uterus