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Ultimately, clear distinction between focal cartilage injury and diffuse degenerative joint disease is essential to determine ACI eligibility, with emerging imaging, biomaterials, and scaffold innovations contributing to expanding its therapeutic window

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Asparagine deprivation enhances T cell antitumour response in patients via ROS-mediated metabolic and signal adaptations

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Clinical and preclinical studies support these antioxidant effects

Abnormal ROS signalling in OA synovial fibroblasts induced by cytokines, thrombin or stress is related to the increased activity of nuclear factor erythroid 2 p45-related Factor 2 (NFE2L2, also known as NRF2) (Bernard et al., 2017)