8 Reasons for less weight loss with GLP1 RAs for T2D could include use of insulin or other obesity-promoting medications, concerns over hypoglycemia, decreased glycosuria, microbiome variation, genetic predisposition towards weight gain, and differences in endogenous GLP-1 pathways in the brain and other tissues
Your Next Steps: Start simple : Begin with 200 mcg before bed, 5-6 days per week Track everything : Monitor sleep, energy, recovery, and body composition Be patient : Allow 4-6 weeks to assess initial effectiveness Adjust gradually : Make small modifications based on your response Consider stacking : Add complementary peptides after establishing your base protocol The journey to optimal health and longevity through peptide therapy requires patience, consistency, and attention to detail
All animal experiments were approved by the Institutional Animal Care and Use Committee of the College of Medicine at Gachon University (approval number: LCDI-2020-0135)
References Lpez-Otn C, et al
Diabetes Care 42 , 10751080 (2019)
E., Hannan, M