how does glp 1 help cardiovascular health GLP-1: A Game-Changer for Heart in Obesity 8 Benefits of GLP‑1's Beyond

Permanent Nature: Unlike medication, which must be taken continuously, surgery is a one-time procedure

Clinical data on semaglutide and tirzepatide shows average weight loss of 12 lbs/week during dose escalation, with steeper losses in months three through six as the dose reaches maintenance

J Clin Invest

454 By reducing MMP expression, GLP-1R stimulation may help preserve the integrity of fibrous caps and mitigate the risk of plaque rupture

Somatostatin secreted by islet delta-cells fulfills multiple roles as a paracrine regulator of islet function

However, not all tested GLP-1RAs have consistently demonstrated reductions in cardiovascular events, and the impact on specific cardiovascular outcomes varied among the effective drugs