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Smooth muscle relaxation occurs through a decrease in [Ca 2+ ] c (Somlyo and Somlyo, 2003), either via an electromechanical mechanismcharacterized by membrane re-polarization or hyperpolarizationor through a pharmacomechanical mechanism, which involves membrane receptor activation and inhibition of the intracellular signaling pathways that drive contraction (Woodrum and Brophy, 2001) (Figure 6)

Research published in Nature Reviews Endocrinology and other medical journals indicates that early studies suggest GLP-1 medications may reduce cravings for substances such as alcohol, nicotine, and highly processed foods

This typically resolves within the first two weeks

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Bope 2012