LC intervention can ameliorate HUA-associated left ventricular anterior wall thickening in mice
Introduction Type 2 diabetes (T2D) is one of the major health concerns affecting 9% of the global population, putting those affected at risk of cardiovascular-associated mortality ( The incretins glucagon-like peptide-1 (GLP-1) and glucose-stimulated insulinotropic polypeptide (GIP) are peptide hormones secreted from intestinal enteroendocrine cells (Nauck and Meier, 2018), with the incretin effect referring to the greater amount of insulin secreted in response to an oral glucose load relative to an equal intravenous dose
Their pronounced hydrophobicity and nonspecific tissue distribution further compound these issues, particularly restricting their application in diseases requiring systemic intervention, such as cancer [106]
Key molecular features include the F23 Cagri residue anchoring the peptide at the receptor transmembrane (TM) bundle level and the micelle, an E14-R17 intramolecular salt bridge enhancing helical stability, and C-terminal P37 Cagri interaction with the receptor ECD
& Evans, A
Glutamine up-regulates MAPK phosphatase-1 induction via activation of Ca 2+ ERK cascade pathway
