32 However many functional practitioners consider even this amount to be inadequate, and encourage working up to 35-50 g/daily depending on individual tolerance
Not because reconstitution is complicated, but because nobody explains the actual math clearly
While both agents struggled with the inherent GI burden typical of GLP-1RAs, efpeglenatides limitations were largely dose-related and within manageable expectations, whereas taspoglutides combination of severe immunogenicity and hypersensitivity reactions rendered it clinically unviable
9.4 Are GLP-1 treatments safe
Only about 4% of people in studies needed to stop the medication because of their GI symptoms, which suggests that with the right support, relief is possible
These findingsoriginating from landmark trials such as EMPA-REG OUTCOME, LEADER, and SUSTAIN-6have led to substantial revisions in international guidelines from the European Society of Cardiology, American College of Cardiology, and American Heart Association, which now recommend the use of SGLT2i or GLP-1 RAs, often in conjunction with metformin
