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PEGylation the covalent attachment of polyethylene glycol (PEG) chains via a succinyl linker surrounds the peptide with a steric hydrophilic shield that dramatically increases hydrodynamic radius, reduces renal filtration, and provides protection from proteolytic degradation

Interaction of oxidative stress and misfolded proteins in the mechanism of neurodegeneration

No receptor desensitization

[DOI] [PMC free article] [PubMed] [Google Scholar] 14.Hecker P

Kumar et al., 1992)

Despite inconclusive evidence regarding its direct impact on STAT3 and TGF-1, the observed positive clinical and biochemical results underscore its potential therapeutic value