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Participants with normal hepatic function were eligible for inclusion if they were judged to be of general good health by the investigator, based on a medical examination (including physical examination, medical history, vital signs and ECG) and had liver enzyme levels within prespecified limits (alanine aminotransferase upper limit of normal [ULN] + 10%, aspartate aminotransferase ULN + 20% and total bilirubin ULN + 20%)

Kellner, H

Clinical Biochemistry

This information could guide platform design and user behavior recommendations

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Thus, the urine drug data method is applicable to most drugs excreted in the urine in their original form, especially when the excretion of the drug or its metabolites accounts for more than 70% of the absorbed dose