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Secondary mitochondrial dysfunction Acquired dysfunction may develop from oxidative stress, inflammation, nutrient deficiency, medication toxicity, toxic exposure, aging, metabolic disease, infection, poor sleep, inactivity or chronic illness

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As antioxidant molecule, glutathione participates in reactions of neutralization of reactive oxygen species (ROS)

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Consequently, current research has focused on identifying novel therapeutic strategies targeting the inflammatory and cell death pathways involved in APAP-induced hepatotoxicity