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Clinical trials showed Retatrutide producing an average 24.2% body weight reduction over 48 weeks at the highest dose tested, making it the most effective weight loss compound ever studied in clinical trials

2018 [cited 2022 Jan 12];14:938

Think of titration like strength training

If semaglutide causes nausea or diarrhea, it could interfere with the patients ability to complete the bowel preparation effectively

It has been studied as a possible modulator of sleep architecture rather than as a sedative

But what happens when the body experiences a stressor is more of that hair is pushed into that quiet phase, which precedes a loss phase about a couple months later