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It is estimated that 1.5 million bone grafting procedures are performed annually in the USA and this figure is rapidly increasing due to population ageing [2, 7, 913]
If the individual has significant accumulation (older age, chronic disease, prior chemotherapy), the first course may produce the most noticeable effects Subsequent courses: Target newly accumulated senescent cells
PMID 22052267 EMJ Dermatology
(2020) 30:154252.e7
Neurobiol Dis 15(3):461473
